Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O6-methylguanine-induced apoptosis

► MAPO1 stabilizes in the course of apoptosis triggered by O6-methylguanine. ► MAPO1 level is regulated by proteasome-dependent degradation pathway. ► Folliculin and AMPK stabilize MAPO1 in positive and negative manners, respectively. ► Folliculin retains an ability to stably bind to MAPO1 during apoptosis. ► AMPK dissociates gradually from MAPO1 during apoptosis.