Formation of spherulitic amyloid β aggregate by anionic liposomes

► Senile plaque, which is observed on a neuronal membrane in patients of Alzheimer's disease, is a spherulitic fibrillar aggregate. ► Fragmented fibrils could interact with anionic liposomes to form spherulitic fibrillar aggregates. ► Anionic liposomes enable a reproducible modeling of a senile plaque of a protein from Alzheimer's disease. ► The fragmentation of fibrils is a crucial for a formation of senile plaques.