Activation of εPKC reduces reperfusion arrhythmias and improves recovery from ischemia: Optical mapping of activation patterns in the isolated guinea-pig heart

► Optical mapping technique was used in hearts to assess reperfusion arrhythmia. ► Peptide specific activator of epsilon PKC had anti-arrhythmic effects. ► Peptide specific inhibitor of epsilon PKC had pro-arrhythmic effects. ► Results are clinically relevant to the treatment of acute ischemic heart disease.