Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

► Curcumin delays the self-assembly of IAPP to NMR-invisible assemblies. ► Curcumin disassembles α-helix in maturing assemblies of IAPP. ► Curcumin modulates the self-assembly of IAPP by disassembling α-helix.