Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway

► BRSK2 interacts with Jab1 in vitro and in vivo. ► BRSK2 co-localizes with Jab1. ► Jab1 promotes BRSK2 degradation via the ubiquitin-proteasome pathway. ► BRSK2-mediated cell cycle arrest at G2/M phase is reversed by Jab1.