Combined anti-tumor effects of IFN-α and sorafenib on hepatocellular carcinoma in vitro and in vivo

► IFN-α and sorafenib show combined anti-tumor effects on HCC in vitro and in vivo. ► IFN-α and sorafenib regulate cell cycle progression and apoptosis of HCC in synergy. ► Sorafenib blocks IFN-α-induced oncogenic signaling but not STAT1 activation.