Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase

► We examine neuron dendrite development in Vps18 conditional knockout mice. ► Lysosome degradative function is required for Purkinje cell dendrite development. ► Lox is degraded by lysosome. ► Lysosome regulates Purkinje cell dendrite development through degrading Lox.