Large conductance Ca2+-activated K+ channels modulate endothelial cell outward currents and nitric oxide release in the intact rat superior mesenteric artery

► Simultaneous recordings of currents and force by means of in situ patch clamp. ► BKCa channels are restricted to the smooth muscle cell of rat mesenteric arteries. ► BKCa channels modulate endothelial cell outward currents via gap junctions. ► BKCa channels modulate ACh-evoked NO release via gap junctions.