Traces of certain drug molecules can enhance heme-enzyme catalytic outcomes

► Known- dapsone and amiodarone enhance liver microsomal heme-enzyme activity. ► Effect of these molecules on various functionally unrelated heme-enzymes was studied. ► μM-pM concentrations of the additives significantly enhanced catalytic outcomes. ► Allosteric influences are discounted; a new mechanism is proposed. ► pM levels of additives enhancing enzyme activity demonstrated.