کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10761843 1050480 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels
چکیده انگلیسی
► The biological function of TrkB-Shc in response to BDNF treatment is assessed. ► We found TrkB-Shc protein levels were decreased when cells were exposed to BDNF. ► TrkB-Shc dampens TrkB-TK+ activity and moreso following BDNF exposure. ► TrkB-Shc protein is more stable following BDNF exposure. ► TrkB-Shc may regulate BDNF-stimulated TrkB-TK+ activity by increasing its degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 420, Issue 2, 6 April 2012, Pages 331-335
نویسندگان
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