Epigallocatechin-3-gallate inhibits apoptosis and protects testicular seminiferous tubules from ischemia/reperfusion-induced inflammation

► Testicular torsion-induced ischemia reperfusion injury causes germ cell death and testis inflammation. ► EGCG treatment before testis reperfusion inhibits DNA damage and protects against germ cell apoptosis and inflammation. ► EGCG down regulates the transcription of the iNOS, MCP-1, p53 and Bax genes. ► EGCG has an anti-inflammatory and anti-apoptotic effects on testicular torsion harmful consequences.