Effects of β-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity

► Pre-administration of β-glucan suppressed restraint stress-induced fecal pellet output. ► β-Glucan suppressed drug-induced fecal pellet output. ► β-Glucan suppressed both visceromotor response and butyrate-induced hypersensitivity to CRD. ► β-Glucan did not affect the pain response in general but specifically affects the visceral pain response.