Activation of voltage gated K+ channel Kv1.5 by β-catenin

► Coexpression of β-catenin increased voltage-gated kV current in Kv1.5 expressing oocytes. ► The effect was not dependent on the stimulation of transcription. ► β-catenin enhances the membrane abundance of Kv1.5. ► β-catenin fosters insertion of Kv1.5 protein into the plasma membrane. ► The effect on Kv1.5 requires the same protein domains that are required for association of β-catenin with cadherin.