Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities

► We quantitatively examine morphological differences in the osteocyte networks. ► We provide a unique way to quantitatively measure the size of the networks. ► Differences in the osteocyte networks suggest distinct mechanoadaptations. ► Differences in the osteocyte networks suggest distinct mechanosensitivities.