Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model

► Luteolin potentiates TRAIL-induced apoptosis in cultured A549 cells and HeLa cells. ► Luteolin enhances TRAIL's antitumor activity in a lung cancer xenograft mouse model. ► Luteolin enhances TRAIL's in vivo antitumor activity through enhancing apoptosis.