Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC

► BMP-4 suppresses granulosa cell apoptosis via PI3K/PDK-1/PKC pathway. ► BMP-7 suppressed granulosa cell apoptosis via PI3K/PDK-1/Akt pathway. ► BMP-4 and BMP-7 are associated with granulosa cell survival via non-Smad pathways.