Multiple targeting motifs direct NRAMP1 into lysosomes

► The lysosomal targeting motifs of NRAMP1 are identified and as follows. ► The first is the NH2-terminal 73-140 amino acids (AA) region containing TMD2. ► The second is the AA.263-334 region containing tyrosine-based motif 327YAPI330. ► The others are two internal signal peptides AA.451-483 and AA.489-522.