Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells

► We determine mechanisms underlying aldosterone-induced apoptosis. ► Aldosterone promotes intracellular ROS production. ► Aldosterone induces endoplasmic reticulum stress. ► Aldosterone induces apoptosis via ROS-mediated, CHOP-dependent activation.