Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells

► Upregulation of Skp2 by IL-6 or Stat3 activation. ► Stat3 activates Skp2 expression through bound to its promoter region. ► Stat3 activates Skp2 expression through recruitment of P300. ► Stat3 activation decreases the P27 stability.