The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein

► Loss of MUC4 reduces proliferation of esophageal cancer cells. ► MUC4 inhibition impairs migration of esophageal cancer cells but not their invasion. ► Loss of MUC4 significantly reduces in vivo tumor growth. ► Decrease of S100A4 induced by MUC4 inhibition impairs proliferation and migration.