Cell death induced by novel procaspase-3 activators can be reduced by growth factors

► We investigate cellular effects of novel procaspase-3 activators PAC-1 and 1541. ► PAC-1 and 1541 induce cell death in PC12 cells and primary neurons. ► EGF completely blocks PAC-1 induced caspase-3 activity. ► EGF can reduce cell death induced by PAC-1 and 1541. ► Relevant for further development of procaspase-3 activators for cancer therapy.