Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease

► FAM13A rs2869967 and XRCC5 rs3821104 are associated with COPD in Chinese Han population. ► No statistically significant association between IREB2 rs2568494 and COPD. ► The discovery of variants may contribute to the development of new therapeutic approaches to COPD.