Nesprin-2 epsilon: A novel nesprin isoform expressed in human ovary and Ntera-2 cells

► A novel epsilon isoform of nesprin-2 has been discovered. ► This 120 kDa protein was predicted by bioinformatic analysis, but has not previously been observed. ► It is the main isoform expressed in a teratocarcinoma cell line and is also found in ovary. ► Like other nesprins, it is located at the nuclear envelope. ► We suggest it may have a role in very early development or in some ovary-specific function.