Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1

► Tumor suppressor REIC/Dkk-3 interacts with dynein light chain, Tctex-1. ► REIC/Dkk-3 and DIC share a motif [-E-X-G-R-R-X-H-] in their Tctex-1 binding region. ► REIC/Dkk-3 and Tctex-1 are co-localized around the ER in human fibroblasts.