The role of 14-3-3β in transcriptional activation of estrogen receptor α and its involvement in proliferation of breast cancer cells

► 14-3-3β interacts with ERα and the interaction is Akt-dependent. ► 14-3-3β regulates the transcriptional activity of ERα in a ligand-dependent manner. ► 14-3-3β increases expressions of ERα target genes. ► 14-3-3β increases breast cancer cell proliferation.