The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia

► Hypoxia is a microenvironmental pathologic factor associated with inflammation. ► MCP-1 is one of the crucial cytokines in inflammation. ► We examine the mechanisms of the repression of MCP-1 expression under hypoxia. ► DNA methylation is attributed to IL-1β-induced MCP-1 expression by hypoxia. ► DNA methylation is associated with transient transcriptional repression.