The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner

► The transcription factor Grainyhead like 3 is expressed in endothelial cells. ► Grainyhead like 3 is required for endothelial cell migration. ► Grainyhead like 3 acts anti-apoptotic in endothelial cells. ► A positive feedback loop exists between NO and Grainyhead like 3 in endothelial cells.