Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells

► Quercetin, a bioactive flavonoid, suppresses expression and enzymatic activity of phospholipase D1. ► Quercetin abolishes NFkB-induced phospholipase D1 expression via inhibition of NFkB transactivation. ► Quercetin-induced suppression of phospholipase D1 inhibits invasion and proliferation of human glioma cells.