Expression of tyrosine hydroxylase is epigenetically regulated in neural stem cells

► Region b/w −2164 and −1210 bp in TH promoter - involved in transcriptional repression of TH gene in NSC-specific manner. ► CpG islands in TH promoter in NSCs were fully methylated at all sites. ► CpG island in SH-SY5Y cells were hypomethylated. ► Treatment with 5-AzadC reactivated expression of the TH gene. ► MeCP2 binds to hypermethylated TH promoter region.