Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish

► Zebrafish SMP30/RGN mRNA expression decreases with aging. ► Decreased expression was observed in liver tumors as compared to the surrounding area. ► SMP30/RGN is important for liver proliferation and tumorigenesis.