Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection

► Oct3/4-positive cells increase in Schistosoma haematobium (SH)-associated bladder cancer. ► iNOS-dependent DNA lesion, 8-nitroguanine, was formed in Oct3/4-positive cells. ► 8-Nitroguanine formed in stem-like cells plays a role in SH-induced carcinogenesis. ► Mutant stem cells may participate in inflammation-related carcinogenesis.