α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model

► α-Pinene disrupts mitochondrial potential and induces apoptosis. ► Biochemical apoptotic hallmarks were evaluated in melanoma treated cells. ► The therapeutic value was confirmed using a murine melanoma metastatic model.