Comparing mechano-transduction in fibroblasts deficient of focal adhesion proteins

► Stretch-mediated signaling and apoptosis are of the order: FAK > p130Ca > vinculin. ► ERK1/2 phosphorylation peaks earlier in FA-deficient cells than in wildtype cells. ► Traction changes of FA-deficient cells are of the order: vinculin > FAK > p130Cas.