Progress in demonstrating total homochiral selection in montmorillonite-catalyzed RNA synthesis

► Na+-montmorillonite catalyzed RNA synthesis from activated d,l-mononucleotides. ► About 63.5% of the dimers produced were homochiral. ► The homochirality increased with increased chain length. ► About 97.2% of the pentamers were homochiral. ► Na+-montmorillonite not only catalyzed RNA synthesis but also facilitated homochiral selection.