Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway

► This article described the effects of the EGFR tyrosine kinase inhibitor on the cell proliferation and the apoptosis induction of the colon carcinoma cell lines. ► Demonstrated that 326474 is a more potent EGFR inhibitor on colon cancer cells than other three TKIs. ► It can be important when considering chemotherapy for colonic cancer patients.