Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms

► Human CTNNA1 and CTNNA2 genes contain alternative 5′ exons. ► These exons share bidirectional promoters with LRRTM2 and LRRTM1 genes. ► Alternative 5′ exon CTNNA1 and CTNNA2 mRNAs are expressed at high levels in the brain. ► N-terminally truncated CTNNA proteins are produced from these alternative CTNNA mRNAs.