Ultrasound-mediated interferon β gene transfection inhibits growth of malignant melanoma

► Successful ultrasound-mediated transfection of melanoma (C32) cells with IFN-β genes both in vitro and in vivo. ► Ultrasound-mediated IFN-β transfection inhibited proliferation of melanoma cells in vitro. ► Ultrasound-mediated IFN-β transfection inhibited melanoma tumor growth in vivo.