Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation

► The cytoskeleton-associated protein, smALP, is expressed in differentiated skeletal muscle. ► smALP is translocated from the cytoplasm to the nucleus of C2C12 myoblasts upon induction of myogenesis. ► The differentiation-dependent nuclear translocation of smALP occurs in parallel with the nuclear accumulation of myogenin. ► The LIM domain of smALP is essential for the nuclear accumulation of the protein. ► smALP might act in the nucleus to control some critical aspect of the muscle differentiation process.