Downregulation of cPLA2γ expression inhibits EGF-induced chemotaxis of human breast cancer cells through Akt pathway

► Downregulation of cPLA2γ significantly impaired EGF-induced directional migration, adhesion and invasion in human breast cancer cells. ► cPLA2γ regulates cancer cell chemotaxis through AKT/PKCζ pathway. ► cPLA2γ plays an important role in cancer cell chemotaxis.