Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator

► TRIM22 selectively activates NF-κB. ► TRIM22-mediated NF-κB activation is dependent on its RING domain and SPRY domain. ► TRIM22 stimulates U937 cells to secret pro-inflammatory cytokines. ► The induction of pro-inflammatory cytokines by TRIM22 is dependent on its effect on NF-κB activity.