Depletion of cellular poly (A) binding protein prevents protein synthesis and leads to apoptosis in HeLa cells

► Depletion of cellular PABP level arrests mRNA translation in HeLa cells. ► PABP knock down leads to apoptotic cell death. ► PABP depletion does not affect transcription. ► PABP depletion does not lead to nuclear accumulation of mRNA.