Msx2 is required for TNF-α-induced canonical Wnt signaling in 3T3-L1 preadipocytes

► We examined the role of Msx2 in TNF-α-activated Wnt signaling in preadipocyte. ► TNF-α transiently enhances the expression and downstream signaling of Wnts. ► TNF-α transiently enhances Msx2 expression. ► Msx2 mediates activation of Wnt signaling by TNF-α in context of antiadipogenesis.