Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats

► Lipid peroxidation and tyrosine nitration are elevated in the adrenal medulla of aged rats. ► Endogenous antioxidant enzymes are depleted in the hypothalamus of very old rats. ► Caloric restriction (40%) prevents the accumulation of 4-HNE in the adrenal medulla of aged rats and attenuates the age-related reduction in antioxidant enzymes in the hypothalamus.