A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis

► Let-7/Fas form a double-negative feedback loop which regulates Fas-mediated apoptosis. ► Fas activation suppresses Dicer processing and let-7 microRNA biogenesis. ► Let-7 inhibitor sensitizes colon carcinoma cells to Fas-related apoptosis.