Calcineurin stimulates the expression of inflammatory factors in RAW 264.7 cells by interacting with proteasome subunit alpha type 6

► CN binds to PSMA6 and regulates proteasomal activity via this interaction. ► CN induces the expression of inflammatory factors. ► CN increases NF-κB activity via proteasome-mediated degradation of IκB. ► These findings reveal a novel process of CN-mediated activation of NFκB.