Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation

► Cilostazol, the phosphodiesterase III inhibitor, attenuates Aβ accumulation and tau phosphorylation via a significant decrease in ApoE-mediated Aβ aggregation. ► Cilostazol improves spatial learning and memory in the Aβ25-35 injected mouse model. ► Cilostazol may be the basis of a novel strategy for the therapy of Alzheimer's disease.