Inhibition of TNF-α-mediated inflammatory responses by a benzodioxolylacetylamino-linked benzothiazole analog in human fibroblast-like synoviocytes

► We synthesized SPA0537, a benzothiazole analog. ► SPA0537 is a potent NF-κB inhibitor. ► SPA0537 suppresses the production of proinflammatory mediators in human rheumatoid fibroblast-like synoviocytes. ► SPA0537 is effective at suppressing osteoclast differentiation.