Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function

► nNOS knockout mice exhibit mild impairments in object recognition memory. ► nNOS knockout mice display working memory deficits, potential impairments in prefrontal cortical functioning. ► nNOS interacts with DISC1, another genetic risk factor for schizophrenia that plays roles for cortical development and prefrontal cortex functioning, in the developing cerebral cortex. ► DISC1-NDEL1 interaction is increased in nNOS knockout mice. ► nNOS knockout mice are useful tools in studying the role of nNOS signaling in cortical development and prefrontal cortical functioning.