کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10764040 1050530 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss
چکیده انگلیسی
► ATP6v0d2 is not required for OVX-induced trabecular bone loss. ► TRAP+ osteoclasts formation and total TRAP activity were increased in ovariectomized WT and ATP6v0d2 KO mice compared with the corresponding SHAM controls. ► WT and ATP6v0d2 KO mice exhibited the equivalent number of CFU-GM in their SHAM and OVX mice, respectively. ► ATP6v0d2 regulates the late stage of osteoclast maturation following estrogen withdrawal. ► ATP6v0d2 has critical role in bone remodeling under normal physiology but not in stressed condition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 403, Issue 1, 3 December 2010, Pages 73-78
نویسندگان
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