Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons

► Cbln1 and Cbln2 induce presynaptic differentiation of cortical neurons. ► Synaptogenic activities of Cbln1 and Cbln2 require the interaction with neurexins. ► Cbln1, Cbln2 and Cbln4 selectively bind to neurexin variants with splice segment 4. ► Cbln subtypes show differential affinities to neurexin variants.